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Support Center Support Center. This study explains why mosapride, a prokinetic drug, improves glycemic control though release of insulin, GLP-1, and the expression of intestinal mucosa sweet taste receptors. Additionally, GLP-2, the other major proglucagon-derived peptide, has potent intestinotrophic effects, such as increasing the rate of mucosal stem cell proliferation, mucosal blood flow, and fluid absorption, as well as augmenting the rate of duodenal bicarbonate secretion in order to improve gastric mucosal health and longevity. Unlike the oral cavity, which contains five distinct classes of taste receptors, the intestines only express three: Short-chain fatty acids and human colonic function: Glucagon-like peptides GLPs play an important role in intestinal regeneration and growth as well as glucose metabolism. Fujiwara K, et al.

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Abstract Purpose of Review To summarize and illuminate the recent findings regarding gastroduodenal mucosal defense mechanisms and the specific biomolecules involved in regulating this process, such as glucagon-like peptides GLPs.

Gastrointestinal Defense Mechanisms

Expressed on brush and enteroendocrine cells, sweet taste receptors are present throughout the gastrointestinal tract, linked to ghrelin and GLP-1 production [ 18 ]. Int J Obes Lond ; 39 3: In a piglet model, SCFA-induced trophic effects occurred in portions of the intestine not originally exposed to the SCFA infusions, suggesting that these trophic effects did not require direct mucosal exposure [ 7 ]. The publisher's final edited version of this article is available at Curr Opin Gastroenterol. Svenska När du köper varan gör du en transaktion med Google Payments och godkänner därmed Google Payments användarvillkor och sekretesspolicy.








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